The MUC1-T1224 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CA 15-3, CA15-3, CD227, KL-6, MAM6, MUC1, and Mucin 1. This antibody recognizes Human antigen. The MUC1-T1224 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
This gene is a member of the mucin family and encodes a
membrane bound, glycosylated phosphoprotein. The protein is
anchored to the apical surface of many epithelia by a transmembrane
domain, with the degree of glycosylation varying with cell type. It
also includes a 20 aa variable number tandem repeat (VNTR) domain,
with the number of repeats varying from 20 to 120 in different
individuals. The protein serves a protective function by binding to
pathogens and also functions in a cell signaling capacity.
Overexpression, aberrant intracellular localization, and changes in
glycosylation of this protein have been associated with carcinomas.
Multiple alternatively spliced transcript variants that encode
different isoforms of this gene have been reported, but the
full-length nature of only some has been determined. [provided by
RefSeq]